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| Home | Score | Away | League | Time (CST) |
|---|---|---|---|---|
| Diriangén | 0:0 | San Marcos de Huari | Nicaragua Primera Division | 08:00 |
| Bolívar | 1:0 | Guabirá | Bolivian Primera División | 08:00 |
| Delfín | 0:0 | Macará | Ecuadorian Serie A | 08:00 |
| Fortaleza | 1:0 | Novorizontino | Brazilian Serie B | 08:00 |
| Londrina | 0:0 | Botafogo-SP | Brazilian Serie B | 08:00 |
| Flint City Bucks | 0:0 | FC Buffalo | USL League Two | 07:30 |
| Lionsbridge FC | 2:1 | Asheville City SC | USL League Two | 07:30 |
| Ventura County Fusion | 0:0 | Project 51O | USL League Two | 07:30 |
| Kansas City Current | 0:1 | San Diego Wave | American NWSL | 08:00 |
| Supra du Québec | 1:2 | Vancouver FC | Canadian Premier League | 07:00 |